Haemocoagulase Acutus (Halase)

a new hemostatic in halase development

is a highperformance thrombinlike enzyme (TLE) derived from snake venom of Agkistrodon acutus. To study the pharmacokinetics of Halase

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Ⅰlabeled radioisotope method and radioassay combined with TCA precipitate were applied in rats. Results showed that AUC values were positively correlated with doses under both used methods

and the correlation coefficients were 0.999 8 and 0.999 0 respectively; drug concentration in liver

spleen and heart reached its peak after 5 minutes of administration while most of other organs reached it in 30 minutes

and then gradually decreased; in each time point

drug concentration in the liver was significantly higher than that in other tissues; Halase was completely excreted and mainly in urine.